As we’ve shared previously in this column, in 1952, Czechoslovakian chemists Otto Wichterle and Dr. Drahoslav Lim successfully synthesized the world’s first hydrophilic plastic known as polyhydroxyethylmethacrylate (pHEMA). Five years later, Wichterle, along with a few willing colleagues, molded the first soft contact lenses. However, due to reduced government funding and the poor quality of the early molded lenses, Wichterle was forced to pursue his dream of a soft contact lens outside of the walls of the university.
Overcoming the Challenges
The first challenge that Wichterle’s team needed to overcome was adhesion of the pHEMA to the mold, which was causing irregular lens edges. In early 1961, Wichterle conceived the idea of spin-casting as a method of manufacturing. Like many great inventions, his inspiration was drawn from the simplicity of everyday life—in this case, while stirring cream into a cup of coffee! He observed how the edges of the cup formed a capillary interaction with the coffee inside (Figure 1) and imagined that this possibly could be applied to his invention.
With a lack of resources, Wichterle had to be innovative in building a machine capable of working the soft gel material into a finished contact lens. In a now famous story, on Christmas Eve 1961, Wichterle built a machine from the Merkur (Erector) set of one of his sons, along with the generator from his bicycle light.
Part of this legendary story is that the toys used for the construction of the original device were gifts for Christmas that year; however, his two sons would have been in their early 20s at that time. It is more likely that these were simply repurposed childhood toys.
From this machine, on Christmas day, Wichterle and his family produced the first four finished, spun-cast soft contact lenses at the family’s kitchen table (Figure 2). The next day, the soft lenses were clinically evaluated by Dr. Maximillian Dreifus of the Second Ophthalmological Clinic in Prague (Figure 3), who found them to be both comfortable and optically successful for his patients.
Christmas 1961 will forever be a landmark moment in the history of contact lenses as the time that a single spark ignited a chain reaction that would forever change the eye-care industry. CLS