Objective:

To explore the relationship between corneal sensitivity and the comfort of gas permeable (GP) lens wear, particularly in patients with keratoconus, highlighting its clinical significance.

Key Findings:

• Corneal sensitivity is one of several factors affecting GP lens comfort, with specific examples of how it interacts with other factors.
• Topical anesthesia can improve initial GP lens fitting comfort but should not be used long-term due to potential complications.
• Corneal sensitivity may decrease with GP lens wear but typically recovers after cessation, with implications for patient management.
• CXL can lead to temporary changes in corneal nerve density and sensitivity, affecting lens tolerance.

Interpretation:

Understanding corneal sensitivity and its impact on lens wear can help improve fitting strategies and patient comfort, especially in those with keratoconus, with potential implications for clinical practice.

Limitations:

• Corneal nerve assessment is challenging and requires further research, particularly in understanding the mechanisms involved.
• The relationship between corneal sensitivity and lens wear comfort is complex and not fully understood, indicating a need for more comprehensive studies.

Conclusion:

Further investigation into corneal sensitivity could enhance GP lens fitting protocols and patient experiences, particularly for those with keratoconus, suggesting specific areas for future research.